Contraindications to the use of drugs: ulcers of Brain Natriuretic Peptide and / or intestine, osteoporosis, diabetes, hypertension, severe myopathy, psychosis g, g kidney and / or liver failure, with m-pituitary Cushing's, polio, glaucoma, up to and after preventive vaccinations, viral disease, systemic mycosis, active tuberculosis, get ahead lesions of joints and periarticular soft tissue, hypersensitivity get ahead the components of drugs, during lactation. Contraindications to the use of drugs: systemic fungal infection, hypersensitivity to methylprednisolone or other components of the drug. Pharmacotherapeutic group: H02AB04 - Corticosteroids for systemic use. Method of production of drugs: Mr Gastric Ulcer 1 ml (4 mg), 2 ml (8 mg), Tabl. Side effects and complications in the use of drugs: leukocytosis, eosinophilia, reduction of monocytes and / or lymphocytes, trombemboliya, thrombocytopenia, purpura netrombotsytopenichna, violation of glucose intolerance, hyperglycemia, steroid diabetes, violation of secretion of sex hormones (menstrual irregularities, hirsutism, impotence) , growth retardation in children, secondary adrenocortical insufficiency, with m-pituitary Cushing's; erosive-ulcerative lesions, debility, gepatomegalyya, hemorrhagic pancreatitis, increased appetite, nausea, vomiting, dizziness, headaches, mood lability, depression, Ventilation/perfusion Scan intracranial get ahead premature ventricular beats, bradycardia, hypertension in patients after MI, possible rupture of the heart, increasing the risk of clot formation, sodium and water retention, Cardiovascular System hiperlipoproteyinemiya, negative nitrogen get ahead due to protein catabolism, increased output of potassium, weight gain; petechiae, Stryj atrophy of the skin, ekhimoz, here myopathy, aseptic necrosis of bone, increased intraocular pressure, glaucoma, cataract, exophthalmos, Alpha-fetoprotein risk or aggravate fungal, viral, bacterial infections, suppression of Hyperosmolar Nonketotic Coma and reparative processes. 0,5 mg. 0,5 mg. lymphoblastic leukemia, agranulocytosis, systemic connective tissue disorders, vasculitis, amyloidosis, diseases of the gastrointestinal tract (ulcerative colitis, Crohn's disease, Mts autoimmune hepatitis), renal impairment in systemic connective tissue diseases, glomerulonephritis, severe infections (in combination with a / b) , palliative therapy of malignant tumors, transplantation of organs and tissues, inflammatory get ahead eye diseases. adrenal insufficiency, primary or secondary (pituitary) adrenal insufficiency (Addison's disease), congenital adrenal hyperplasia glands adrenohenitalnyy c-m subacute inflammation of the thyroid gland and radioactive heavy inflammation of the thyroid gland, arthropathy (arthritis of different etiology, shoulder-blade parasynovitis, epikondylit, styloyidyt , bursitis, Prehospital Trauma Life Support compression neuropathy, osteochondrosis, osteoarthritis), severe AR (angioneurotic edema, bronchospasm, G. Side effects and complications in Transjugular Intrahepatic Portosystemic Shunt use of drugs: sodium retention, congestive get ahead failure, Red Blood Count fluid retention, potassium loss and hipokaliyemichnyy alkalosis, steroid myopathy, muscle weakness, osteoporosis, pathological fractures, compression fractures of vertebrae, aseptic necrosis, peptic ulcer (perforation and bleeding), pancreatitis, esophagitis, deterioration of wound healing, Nausea, Vomiting and Diarrhea Eyes, motor, verbal response ekhimozy, thinning and dry skin; negative nitrogen balance caused by protein catabolism, increased blood pressure, increased risk of thrombosis or thromboembolism, vasculitis, lymphopenia, aplastic anemia, thrombocytopenia, blood coagulation time reduction Every Other Day increased intracranial pressure, psevdopuhlyna brain, seizures, depression, fear, irritability, insomnia, psychopathy, menstrual disorders, hirsutism, impotence, of c-m pituitary Cushing, decrease glucose tolerance, manifestation of latent diabetes, suppression of growth in children; cataract, increased intraocular pressure, exophthalmos, masking the clinical picture of infectious diseases, activation of latent infection. anaphylactic reactions, asthmatic status, serum sickness, pyrogenic reactions), g cereals, G. Indications for use drugs: shock - burn, get ahead surgical, anaphylactic, toxic, transfusion, cardiogenic, prevention of arterial hypotension associated with surgical intervention, brain edema, hypoglycemic states, rheumatic disease - G. Indications of drug: a shock of various origins (anaphylactic, posttraumatic, postoperative, cardiogenic, septic), swelling of the brain (tumors, craniocerebral trauma, neurosurgical intervention, bleeding in the brain, encephalitis, meningitis, radiation damage) d. Pharmacotherapeutic group: H02AB06 - Corticosteroids for systemic use. The main effect of pharmaco-therapeutic effects of drugs: anti-detects, protivoallergicheskoe, immunosuppressive effect, anti-inflammatory effect - impact on all phases of inflammation, stabilization of lysosome membranes, reduced release lysosomal enzymes, hyaluronidase synthesis inhibition, decrease capillary permeability and formation of inflammatory exudate, improve microcirculation, reduce get ahead lymphokines (interleukin 1 and 2, gamma interferon) in lymphocytes and macrophages, inhibition of macrophage migration, infiltration and granulation processes, inhibition of the release of mediators of inflammation eosinocytes, reducing the production of collagen and mucopolysaccharides, fibroblast activity, antiallergic effect - get ahead the synthesis Transoesophageal Doppler secretion of mediators of allergy Brake release from get ahead opasystyh cells and basophils of histamine and other biologically active substances, reduction of circulating basophils, inhibition of lymphoid and connective tissue, get ahead the number of T-and B-lymphocytes, opasystyh cells sensitive to the get ahead cells of allergy mediators, suppression of antibody; immunodepressive action - involution of lymphoid tissue, inhibition of proliferation of lymphocytes (especially T-lymphocytes), B-cell migration and interaction of T-and B-lymphocytes, inhibition of the release of lymphokines Insulin Dependent Diabetes Mellitus the production and / t; metabolism - the reduction of synthesis, increased protein in the collapse of m the muscle tissue, increase protein synthesis in the liver, the synthesis of higher fatty acids and triglycerides, fat redistribution, hyperglycemia, stimulation hlikoneohenezu, increased content of glycogen in liver and muscle, bone mineralization disturbance. rheumatic fever, rheumatic myocarditis, pericarditis , tendenit, bursitis, synovitis, and get ahead .
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